Mosca is an Italian surname. Notable people with the surname include:
Alessia Mosca (born 1975), Italian politician Angelo Mosca (1937–2021), Canadian Football League player and professional wrestler Antonio Mosca (1870–1951), Italian painter Bianca Mosca (dead 1950), London-based fashion designer Claudio Mosca (born 1991), Argentine footballer Enrique Mosca (1880-1950), Argentine lawyer and politician Frank Mosca (born 1976), American film producer Gaetano Mosca (1858–1941), Italian political scientist, journalist, and public servant Giuseppe Mosca (1772–1839), Italian opera composer Jacopo Mosca (born 1993), Italian cyclist John Mosca (restaurateur) (1922–2011), American restauranteur, founder of Mosca's John Mosca (musician) (born 1950), American jazz trombonist Lino Mosca (1907−1992), Italian professional football player Luigi Mosca (1775–1824), Italian composer of operas and sacred music, and singing teacher Maurizio Mosca (1940–2010), Italian sports journalist and television presenter Michele Mosca, Italian physics researcher and professor of mathematics Paolo Mosca (1943–2014), Italian journalist, writer, singer, and television presenter Pierre Mosca (born 1949), Italian-born French former footballer and coach Rafael Mosca (born 1982), Brazilian swimmer Rich Mosca (born c. 1948), former American football player and coach Sal Mosca (1927–2007), American jazz pianist Simone Mosca (1492–1554), Italian sculptor Stefania Mosca (1957–2009), Venezuelan writer Tommaso Mosca (born 2000), Italian racing driver
Fictional characters Mosca, of Ben Jonson's 1606 play Volpone Mosca, of The Godfather Part III Frank Mosca, of Miami Vice Gola Mosca, of Reborn! manga and anime series Walter Mosca, of Mario Puzo's novel The Dark Arena