Region 2 or Region II may refer to:
Government Region 2, Northwest Territories, a Statistics Canada census division Former Region 2 (Johannesburg), an administrative district in Johannesburg, South Africa, from 2000 to 2006 Cagayan Valley (designated as Region II), an administrative region in the Philippines One of the regions of Iran
Technology DVD region 2, one of the DVD regions ITU Region 2, consisting of the Americas