M22, M.22 or M-22 may refer to:
Transportation Aviation BFW M.22, prototype, 1928 German bomber Jancsó-Szokolay M22, 1937 Hungarian sailplane Magni M-22 Voyager, autogyro Mooney M22 Mustang, 1964 American light aircraft Shvetsov M-22, a Soviet version of the Bristol Jupiter aircraft engine Russellville Municipal Airport (FAA LID: M22)
Road transport M22 (New York City bus), a New York City Bus route in Manhattan Highway M22 (Ukraine) M-22 (Michigan highway), a state highway in Michigan M22 (Cape Town), a Metropolitan Route in Cape Town, South Africa M22 (Johannesburg), a Metropolitan Route in Johannesburg, South Africa M22 (Pretoria), a Metropolitan Route in Pretoria, South Africa M22 (Durban), a Metropolitan Route in Durban, South Africa M22 road (Malawi) M22 motorway (Northern Ireland)
Military HMS M22, Royal Navy M15 class monitor; later HMS Media M22 Locust, a light tank of World War II M-22 Uragan/Shtil (SA-N-7, Gadfly), Soviet naval multirole SAM system M22, the US Army designation for a type of 7x50 binoculars produced by Steiner-Optik
Other M 22, a political movement of the 1970s and 1980s in Congo-Brazzaville M22, a vitrification agent or cryoprotectant, used in cryonics and cryopreservation The Mathieu group M22 in the mathematical field of group theory M22 graph, in graph theory Messier 22, a globular cluster in the constellation Sagittarius Mälar 22, sailboat class M-22 (duo), a British-German DJ and producer duo consisting of Matt James and Frank Sanders. M22, an ISO metric screw thread size McLaren M22, a Formula 5000 racing car