Cathedral of the Holy Cross or Holy Cross Cathedral may refer to:
Africa Cathedral of the Holy Cross, Lagos, the Roman Catholic Cathedral in Lagos, Nigeria Cathedral of the Holy Cross, Lusaka, the Anglican cathedral in Lusaka, Zambia
Asia Cathedral of the Holy Cross, Gyumri, an Armenian Catholic cathedral in Gyumri, Armenia Armenian Cathedral of the Holy Cross, on Akdamar Island in Van Lake, Turkey Cathedral of the Holy Cross, Tyre, Lebanon Cathedral of the Holy Cross, Acre, Israel
Europe Cathedral of the Holy Cross and Saint Eulalia, the Roman Catholic cathedral in Barcelona, Catalonia, Spain Church of the Holy Cross, Nin, the former Roman Catholic cathedral of Nin, Croatia Cathedral Basilica of the Holy Cross, Opole, Poland Temple of the Exaltation of the Holy Cross, a Greek Catholic cathedral in Bratislava, Slovakia Russian Church, Geneva, a Russian Orthodox cathedral in Geneva, Switzerland Greek Catholic Cathedral, Uzhhorod, Ukraine
North America Cathedral of the Holy Cross (Boston), the current Roman Catholic cathedral in Boston Holy Cross Church, Boston, the first Roman Catholic cathedral in Boston Metropolitan Cathedral Church of the Holy Cross, Our Lady of Regla, and St Francis of Assisi, the Roman Catholic cathedral in Chihuahua, Mexico Holy Cross Armenian Cathedral (Montebello, California), an Armenian Apostolic Church cathedral Holy Cross African Orthodox Pro-Cathedral, New York City Holy Cross Cathedral, Loganville, Georgia, the cathedral of the Anglican Diocese of the South
Oceania Holy Cross Cathedral, Geraldton, the cathedral of the Anglican Diocese of North West Australia, in Geraldton, Western Australia Holy Cross Pro-Cathedral, Vanimo, the pro-cathedral of the Roman Catholic Diocese of Vanimo, Papua New Guinea