Matossian may refer to:
22776 Matossian, a minor planet
People with the surname Alexander Matossian, Lebanese politician Mariam Matossian, Canadian musician Mary Kilbourne Matossian (1930–2023), American historian Nouritza Matossian (born 1945), British Cypriot writer, actress, broadcaster and human rights activist Matossian family, tobacco merchants established in Belgium; see Armenians in Belgium