Matsuki (written: or ) is a Japanese surname. Notable people with the surname include:

, Japanese baseball player and manager , Japanese politician , Japanese voice actress Samizu Matsuki (born 1936), Japanese artist and educator , original name Zhao Dayu, China-born Japanese footballer and manager , Japanese footballer and manager

Matsuki (written: ) is also a masculine Japanese given name. Notable people with the name include:

, Japanese physician

See also 8693 Matsuki, a main-belt asteroid