Succinyl-diaminopimelate desuccinylase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from a number of blue-green algae and bacteria including Escherichia coli hydrolyses N-succinyl-LL-2,6-diaminopimelic acid to diaminopimelic acid and succinic acid. The product is a biosynthetic precursor to the amino acid, L-lysine. Inhibitors of the enzyme have been sought as potential antibiotics. An X-ray structure of the enzyme has been obtained to assist in the design of inhibitors.
This enzyme is a of hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is . This enzyme is also called and DapE.
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