Glycyrrhizinate β-glucuronidase () is an enzyme that catalyzes the chemical reaction

The enzyme characterised from Aspergillus niger removes the glycoside unit from the saponin, glycyrrhizin, to give 2-(β-D-glucpyranosyluronic acid)-D-glucuronic acid (1) and the steroid, enoxolone.

The enzyme is a hydrolase, specifically a glycosidase that hydrolyses O- and S-glycosyl compounds. The systematic name is glycyrrhizinate glucuronosylhydrolase. Other names include glycyrrhizin β-hydrolase, glycyrrhizin hydrolase, and glycyrrhizinic acid hydrolase.

See also α-Glucuronidase β-Glucuronidase Glucuronosyl-disulfoglucosamine glucuronidase

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