Inosinate nucleosidase () is an enzyme characterised from Aspergillus species that catalyses the hydrolysis of the nucleotide, inosinic acid, to D-ribose 5-phosphate and hypoxanthine:

This enzyme is a hydrolase, specifically a glycosylase that hydrolyses N-glycosyl compounds. The systematic name of this enzyme class is 5'-inosinate phosphoribohydrolase.

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