AFE or Afe may refer to:
Association football Afrique Football Élite, a club in Bamako, Mali Association of Spanish Footballers ()
Government, military and politics State Railways Administration of Uruguay (), Uruguay Afe Ichong, a political unit of the Annang people of Nigeria Armed Forces Entertainment, a United States Department of Defense agency Assembly of French Citizens Abroad, France
Places AfE-Turm/Uni-Turm (English: AfE Tower), a demolished skyscraper in Frankfurt, Germany Kake Airport, Alaska, United States (FAA LID:AFE)
Technology Active front end, in variable-frequency drives Advanced FLOW engineering (aFe), a manufacturer of high performance automotive parts Analog front-end, in electronics
Other uses Amniotic fluid embolism, a pregnancy complication Authorization for expenditure, or cost, in accounting Putukwam language, spoken in Nigeria (ISO 639-3:afe)