IPSS may refer to:
Medicine Inferior petrosal sinus sampling, a procedure to help distinguish types of Cushing's disease International Prognostic Scoring System, an evaluation method to determine the severity of myelodysplastic syndrome International Prostate Symptom Score, a short questionnaire to help screen for benign prostatic hyperplasia (BPH)
Other Infrasonic passive seismic spectroscopy, a geological exploration and monitoring technique International Packet Switched Service, a telecommunications data transmission protocol Institute for Peace and Security Studies, a university in Ethiopia
See also IPS (disambiguation)