Prozac is a proprietary name for the antidepressant drug fluoxetine.

Prozac or similar permutations may also refer to:

Prozac+, an Italian punk band Prozak (rapper), American rapper Prozzäk, a Canadian pop band The Prozacs, American musical group "Prosac", a 1996 single by Tomcraft

See also Prozac Nation (book), a memoir by Elizabeth Wurtzel published in 1994 Prozac Nation (film), a 2001 film based around the book