Nothnagel is a German surname. Notable people with the surname include:
Anke Nothnagel (born 1966), East German sprint canoeist Dominik Nothnagel (born 1994), German footballer Hermann Nothnagel (1841–1905), German internist José Sáinz Nothnagel (1907–1984), Spanish politician Johann Andreas Benjamin Nothnagel (1729–1804) German Jewish painter