Frank Grimes (1947–2025) was an Irish actor.
Frank Grimes may also refer to:
Frank Grimes, a character in The Simpsons from the episode "Homer's Enemy" Frank Grimes, Jr., son of Frank Grimes, from The Simpsons episode "The Great Louse Detective" Lt. Frank Grimes, character in the 2002 movie John Q. Francis "Frank" Grimes, character in the show Ugly Americans