Adam Aleksander Sanguszko (; – 1653), of Pogoń Litewska, was a Ruthenian noble of the Polish–Lithuanian Commonwealth.Kubiĭovych, Volodymyr and Husar, Danylo Struk (editors) (1993) "Sanguszko, Adam Oleksander" Encyclopedia of Ukraine: Volume 4, Ph-Sr University of Toronto Press, Toronto, Canada, page 532, He was the castellan of Kiev from 1618, voivode of Podole from 1621 to 1630, voivode of Wołyń from 1630, and starosta of Włodzimierz (until 1625).
His parents were Hryhoryi Sanguszko and Zofia Hołowczyńska. He married Katarzyna Uchańska () before 1616. They had no children and the Sanguszko-Koszyrski line became extinct with Adam's death.
During the royal election in 1648, he seemed to have supported the Ruthenian Eastern Orthodox nobles and the Cossacks, arguing for the need to reform or annul the Union of BrestMironowicz, Antoni "Kościół prawosławny w XVII wieku" ("The Orthodox Church in the 17th Century") Беларускага Гістарычнага Таварыства (Belarusian Historical Society), in Polish, archive from 21 May 2007 In 1637, he founded the Kamień Dominicans.Stolarski, Piotr (2010) Friars on the Frontier: Catholic Renewal and the Dominican Order in southeastern Poland, 1594–1648 Ashgate, Farnham, Surrey, England, page 90,
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