Michael Simpson or Mike Simpson may refer to:
Entertainment Michael Simpson (painter) (born 1940), English painter Michael Simpson (producer), American record producer and member of the electronic group Dust Brothers Mike Simpson (Caulfields), guitarist of the rock group The Caulfields Mickey Simpson (1913–1985), American actor M. J. Simpson, British movie journalist, author and screenwriter Michael A. Simpson, director of sequels to the cult horror film Sleepaway Camp
Politics Mike Simpson (Michigan politician) (1962–2009), member of the Michigan House of Representatives Mike Simpson (born 1950), U.S. congressman from Idaho
Sports Mike Simpson (American football) (born 1947), American football player Michael Simpson (footballer) (born 1974), British footballer Mike Simpson (racing driver) (born 1983), British racing driver
See also Michael Simpson Culbertson (1819–1862), American clergyman and missionary