CSX Transportation is a United States railroad company.

CSX may also refer to:

CSX Corporation, the above railroad system's parent company IATA code for Changsha Huanghua International Airport Cambodia Securities Exchange Shelby CSX, a limited-production performance automobile based on the Dodge Shadow Acura CSX, an entry-level luxury car from Acura, designed and sold in Canada Centre-left coalition, an alliance of political parties in Italy