USS Defiance may refer to the following ships of the United States Navy:
, a cargo vessel in service from 1918–1919 , a coastal minesweeper that served during World War II , a patrol gunboat that served from 1969 until 1973 when it was transferred to Turkey
See also Defiance (disambiguation)
, U.S. Navy tugboat , a DARPA uncrewed surface vessel U.S. drone warship