Speroni is an Italian surname. Notable people with the surname include:
Carlo Speroni (1895–1969), Italian runner Francesco Speroni (born 1946), Italian politician Julián Speroni (born 1979), Argentinian footballer Remo Speroni (1938–2010), stage name Remo Germani, Italian singer Sperone Speroni (1500–1588), Italian humanist playwright