Frank Greene may refer to:
Frank L. Greene (1870–1930), United States representative and senator from Vermont Frank David Greene (born 1963), American trumpet player author, and speaker Frank S. Greene (1938–2009), American scientist and venture capitalist Frank Greene (singer) (1879–?), English baritone in Australia
See also Francis Vinton Greene (1850–1921), United States Army general Frank Green (disambiguation)