O'Kelly or Kelly is an Irish surname. It derives from the Kings of Uí Maine.

Notable people with the surname include:

Aloysius O'Kelly (1853–1936), Irish painter, brother of James Joseph O'Kelly Auguste O'Kelly (1829–1900), music publisher in Paris Christopher O'Kelly (1895–1922), Canadian recipient of the Victoria Cross Don O'Kelly (1924–1966), American actor Edward Peter O'Kelly (1846–1914), Irish politician Gabriel O'Kelly (died 1731), Irish clergyman George O'Kelly (1831–1914), Franco-Irish pianist and composer Henri O'Kelly (1859–1938), Franco-Irish composer, pianist and organist James O'Kelly (1735–1826), American Methodist clergyman James O'Kelly (politician) (1845–1916), Irish politician, brother of Aloysius O'Kelly John J. O'Kelly (1872–1957), Irish politician Joseph O'Kelly (1828–1885), Franco-Irish composer and pianist Malcolm O'Kelly (born 1974), Irish rugby player Roger Demosthenes O'Kelly (1880–1962), African-American lawyer Seán T. O'Kelly (1882–1966), Irish politician, second President of Ireland Seumas O'Kelly (1881–1918), Irish writer

Fictional characters Manuel Garcia O'Kelly-Davis, protagonist of The Moon Is a Harsh Mistress by Robert A. Heinlein Michael the O'Kelly, hero of seven books by Manning O'Brine One of the titular families in The Kellys and the O'Kellys, the second novel of Anthony Trollope

See also Albéric O'Kelly de Galway (1911–1980), Belgian chess grandmaster Mary O'Kelly de Galway (1905-1999), Irish Belgian resistance operative