Ioseliani or Iosseliani () is a Georgian surname. Notable people with this surname include:
Jaba Ioseliani (1926 – 2003), Georgian politician and military commander Nana Ioseliani (born 1962), Georgian chess player Platon Ioseliani (1810 – 1875), Georgian historian Otar Iosseliani (1934 – 2023), Georgian-French film maker Otia Ioseliani (1930 – 2011), Georgian writer Yaroslav Iosseliani (1912 – 1978), Soviet submarine commander