UPW may refer to:

Ultimate Pro Wrestling, a defunct professional wrestling promotion Ultrapure Water, a type of water used during semiconductor manufacturing or chem./physics experiencies Union of Post Office Workers, the former name of the Union of Communication Workers, in the United Kingdom Union Pacific West Line, a rail line in Chicago, Illinois, US United Public Workers (later United Public Workers of America) UPW, the National Rail station code for Upwey railway station, Dorset, England Upwey railway station, Melbourne UP Warriorz, Indian cricket franchise