Two by Two, two by two, 2×2 or 2by2 may refer to:

Arts, entertainment and media

Literature

Two by Two (novel), a 2016 novel written by Nicholas Sparks

Film and television 2×2 (TV channel), a TV channel in Russia Two by Two, or Ooops! Noah Is Gone..., a 2015 animated film "Two by Two" (Balamory), a 2002 television episode "Two By Two", a Rugrats TV episode

Music and musicals Two by Two (musical), a 1970 Broadway show with music by Richard Rodgers

Albums Two by Two (album), by Blue Zoo, 1983 2x2 (album), a boxed set of albums by Milli Vanilli, 1989 2 X 2, a 1997 album by Gigi II x II, a 1970 album by The Cowsills

Songs "Two by Two", from the musical The Book of Mormon "Two By Two", a song by Quasi from the 1999 album Field Studies "2 X 2", a song by Bob Dylan from the 1990 album Under the Red Sky Two by Two, a 1988 song by Cristiana Cucchi

Construction In North America, 2 × 2 is one of several nominal sizes (in inches) of softwood lumber used for purposes such as deck railing

Other uses 2x2, a two-wheeled two-wheel drive vehicle 2by2, an American lottery game 2x2 Project, a public health journalism initiative Two-by-two matrix, a square matrix of order 2

See also Two (disambiguation) 2+2 (disambiguation) Two two (disambiguation) Pocket Cube, a puzzle device also known as a 2×2×2 Rubik's Cube Two by Twos, a Christian based religious movement/organization