Middletown High School can refer to:

Middletown High School (California) in Middletown, California Middletown High School (Connecticut) in Middletown, Connecticut Middletown High School (Delaware) in Middletown, Delaware Middletown High School (Maryland) in Middletown, Maryland Middletown High School North, in Middletown Township, New Jersey Middletown High School South, in Middletown Township, New Jersey Middletown High School (New York) in Middletown, Orange County, New York Middletown High School (Ohio) in Middletown, Ohio Middletown Area High School (Pennsylvania) in Middletown, Dauphin County, Pennsylvania Middletown High School (Rhode Island) in Middletown, Rhode Island

See also Middleton High School (disambiguation)