William Markham may refer to:
William Markham (bishop) (1710–1807), English scholar and religious figure William Markham (governor) (1635–1704), first acting governor of colonial Pennsylvania William Markham (mayor) (1811–1890), Atlanta businessman and mayor William Markham (MP) (by 1533–1571), MP for Nottingham (UK Parliament constituency) William H. Markham (1888–1958), Wisconsin politician William Orlando Markham (1818–1891), English physician and pioneer of cardiology