Custis is a surname which may refer to:
People related to George Washington Daniel Parke Custis (1711–1757), son of John Custis and first husband of Martha Washington Eleanor Parke Custis Lewis (1779–1854), step-granddaughter of George Washington George Washington Parke Custis (1781–1857), son of John Parke Custis and adopted son of George Washington Hancock Custis, a member of the Virginia House of Burgesses (1710–1712), brother of John Custis John Custis (1678–1749), member of the Virginia governor's Council and father of Daniel Parke Custis John Parke Custis (1754–1781), son of Daniel Parke Custis and stepson of George Washington Martha Washington (1731–1802), Martha Custis (as the widow of Daniel Custis) before she married George Washington Mary Anna Custis, daughter of George Washington Parke Custis and wife of General Robert E. Lee Mary Custis Vezey (1904–1994), poet and translator, related through her father, Henry Custis Vezey (1873–1939) Mary Lee Fitzhugh Custis (1788–1853), wife of George Washington Parke Custis
Others Ace Custis (born 1974), American retired professional basketball player Bernie Custis (1928–2017), first black quarterback in North American football Donald L. Custis (1917–2021), United States Navy vice admiral