Sithole is a surname of Zulu origin, and may refer to:
Ana Rita Sithole, Mozambican politician Edson Sithole (1935–1975), Rhodesian lawyer Emmanuel Sithole (born 2003), South African author Gerald Sithole, English footballer Lucas Sithole (1931–1994), South African sculptor Lucas Sithole (tennis) (born 1986), South African Professional Wheelchair Tennis Player Majozi Sithole, Swazi politician Moses Sithole (born 1964), South African serial killer Ndabaningi Sithole (1920–2000), Zimbabwean politician Petros Sithole, South African politician Robert Sithole (1945–2006), South African musician Sphephelo Sithole (born 1999), South African footballer Xoliswa Sithole (born 1967), South African filmmaker