Margaret Kelly may refer to:
Margaret Kelly (civil servant), acting director of the United States Mint by 1911 Margaret B. Kelly (born 1935), American accountant and politician from Missouri Margaret Kelly (dancer) (1910–2004), Irish dancer and the founder of the Bluebell Girls dance troupe Margaret Kelly (swimmer) (born 1956), British swimmer Margaret Kelly (pharmacologist) (1906–1968), American pharmacologist Margaret Skillion (née Kelly), sister of Australian bushrangers Ned Kelly and Dan Kelly Margaret Kelly, first wife of Bill Murray