Lepenica may refer to:
Bosnia and Herzegovina Lepenica (Fojnička River), a river Lepenica (Rogatica), a village Lepenica, Tešanj, a village
Croatia Lepenica, Croatia, a village near Šibenik
Serbia Lepenica (Great Morava), a river Lepenica (region), a region Lepenica (Vladičin Han), a village Lepenica, Mačva, a village Lepenica (Kolubara), a river, right tributary to Kolubara