Spruill is a surname. Notable people with the surname Spruill include:
Benjamin Spruill (fl. 1779), American politician Godfrey Spruill (c. 1650–c. 1719), Scottish-American doctor Hezekiah Spruill (1732–1804), American revolutionary Hezekiah G. Spruill (1808–1874), Confederate general Wild Jimmy Spruill (1934–1996), American session guitarist Joseph Spruill (b. c. 1690), American politician Lionell Spruill (b. 1946), American politician Marquis Spruill (b. 1991), American football player Samuel Spruill (d. 1760), American politician Shannon Spruill (b. 1975), American professional wrestler known as Daffney Zeke Spruill (b. 1989), American baseball player