A80 or A-80 may refer to:
A80 road (Scotland), a major road in Scotland Autovía A-80, a road connecting Ribadesella and Cangas de Onis, Spain HLA-A80, an HLA-A serotype Atlanta TRACON (designated A80), an FAA terminal radar approach control (TRACON) facility for the Atlanta area Dutch Defence, in the Encyclopaedia of Chess Openings A fourth generation Toyota Supra (ID code: A80) AAT (disambiguation) Samsung Galaxy A80, phone manufactured by Samsung Electronics