Zygaena is a genus of moths in the family Zygaenidae.
Zygaena may also refer to:
Sphyrna zygaena, the smooth hammerhead shark Zygaena dissimilis and Zygaena mokarran, synonyms of the great hammerhead shark, Sphyrna mokarran Zygaena blochii, Zygaena laticeps, Zygaena latycephala, synonyms of the winghead shark, Eusphyra blochii Zygaena lewini, Zygaena erythraea, obsolete names for the scalloped hammerhead shark, Sphyrna lewini Zygocranchia zygaena, a synonym for Galiteuthis armata, the armed cranch squid