The House of Knowledge () was a medieval Egyptian university built in Cairo, Egypt in 1004 CE. Originally a library, the House of Knowledge was converted to a state university by the Fatimid Imam-Caliph al-Hakim bi-Amr Allah in the same year.

In keeping with the Islamic tradition of knowledge, the Egyptians collected books on a variety of subjects and their libraries attracted the attention of scholars from around the world. Al-Hakim was a great patron of learning and provided paper, pens, ink and inkstands without charge to all those who wished to study at the House of Knowledge.

See also House of Wisdom Al-Mu'ayyad fi'l-Din al-Shirazi Library of Alexandria Al-Azhar University Madrasa Nalanda mahavihara Fatimid Great Palaces

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