Manfredini is an Italian surname. Notable people with the surname include:
Achille Manfredini (1869–1920), Italian architect and engineer Aparicio Méndez Manfredini (1904–1988), Uruguayan politician Christian Manfredini (born 1975), Côte d'Ivoire-Italian footballer Elisabetta Manfredini-Guarmani (1780–after 1828), Italian opera singer Fernando Salinas Manfredini (born 1956), Chilean activist Francesco Manfredini (1684–1762), Italian Baroque composer, violinist, and church musician Harry Manfredini (born 1943), American musician Niccolò Manfredini (born 1988), Italian footballer Pedro Manfredini (1935–2019), Argentine footballer Renato Russo (1960–1996), Brazilian musician, birth name Renato Manfredini, Jr. Thomas Manfredini (born 1980), Italian footballer Vincenzo Manfredini (1737–1799), Italian composer, harpsichordist and music theorist Manfredini family of painters (Cremona) from the 18th and 19th centuries, included father Giovanni (1730–90), and his three sons, Paolo (1754–1805), Giuseppe, and Serafino
See also Memorial Argo Manfredini, an Italian tennis tournament