Gain or GAIN may refer to:

Electronics and computing Gain (electronics), a measure of the ability to increase the power or amplitude of a signal Gain (antenna), a key performance parameter which combines the antenna's directivity and radiation efficiency Gain (laser), the amplification of optical power involved in laser emission Gain (projection screens), a measure of brightness Information gain (decision tree), in mathematics and computer science Gain, the term in adaptive control literature for learning rate, a step size tuning parameter in optimization algorithms

Biology and health GAIN domain (G-protein-coupled receptor autoproteolysis-inducing domain) Primary and secondary gain, psychological mechanisms that may underlie an illness Global Appraisal of Individual Needs, a set of psychological assessment instruments Global Alliance for Improved Nutrition, a Swiss non-profit foundation working in the field of malnutrition Generating Antibiotic Incentives Now, Title VIII of the United States's Food and Drug Administration Safety and Innovation Act of 2012

Arts Gain (singer) (Son Ga-in, ; born 1987), a South Korean entertainer Gain (novel), 1998, by American author Richard Powers, about Clare International and Laura Bodey Gain (EP), 2009, by Japanese band Sadie

Economics and finance Gain (accounting), an increase in market value relative to purchase price of an asset GAIN Capital Holdings, Inc. (founded 1999, acquired 2020), a US-based trading company specializing in foreign exchange (forex) Greater Avenues to Independence program, the California implementation of Aid to Families with Dependent Children (AFDC), and a precursor to CalWORKs

Other uses Gain (surname), anglicised form of Gayen () Bob Gain (1929–2016), an American professional football player Charles Gain (1923–2018), an American police official Peter Gain (born 1976), a British former professional footballer Gain (detergent), a Procter & Gamble brand

See also Gein (disambiguation) Gayn (disambiguation) Gane, a name Gian, a name ; terms unrelated to those mentioned above include: Gainer (disambiguation), names and terms Gain of function (disambiguation), medical terms Gaina (disambiguation), people and more Gainsborough (disambiguation), places, people, and more Gaines (disambiguation), places and people Gainford (disambiguation), places Gainesville (disambiguation), places in the United States Gainneville, a commune in France Gain Glacier, in the Kvinge Peninsula on Antarctica Gain Creek, a river in Canada GainJet, a Greek charter airline GainSpan, a Wi-Fi technology company Gain-field encoding, in neuroscience Gain Ground, a 1988 action arcade video game by Sega Gain-ground, a type of sport Gain line, in rugby union "Gain Clout", a song from Slime Language by YSL Records and Young Thug, 2018 Gain stage, in audio engineering Gain scheduling, in control theory Gain graph, a type of mathematical structure Fusion energy gain factor Weight gain, an increase in human body mass