Knuckle Sandwich may refer to:
Knuckle sandwich, an idiom for a punch in the mouth
Music "Knuckle Sandwich", a 2003 song by Danger Mouse and Jemini from Ghetto Pop Life "Knuckle's Sandwich", a 2007 song by Gargamel! KnuckleSandwich Records, founded by Scott H. Biram
Other uses Knuckle Sandwich (video game), a 2023 role-playing game Knuckle Sandwich, a 2004 film starring Morgan Fairchild and Eric Stonestreet