Santo Tomé is a city in the province of Santa Fe, Argentina. It is located only 9 km from the capital city (Santa Fe). It has a population of about 65,684 inhabitants ()and estimated at 80,000 inhabitants based on population growth rate provided by the INDEC, and is classified as a second-category municipality.

History The town of Santo Tomé was founded in 1872 by the provincial government, and became a city on 12 April 1962.

Notable people Virginia Tola, operatic soprano Spreen, number one streamer by Argentina and top international

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