Kagame is a surname. Notable people with the surname include:
Alexis Kagame (1912–1981), Rwandan historian Ange Kagame (born 1993), Rwandan philanthropist Jeannette Kagame (born 1962), First Lady of Rwanda Kayije Kagame (born 1987), Rwandan–Swiss artist and actress Paul Kagame (born 1957), President of Rwanda Shyaka Kagamé (born 1983), Rwandan–Swiss filmmaker
See also Kagame Inter-Club Cup, a football club competition also known as the CECAFA Club Cup Kagami (disambiguation)