Metamizil is a central anticholinergic drug and a tranquilliser with powerful sedative and hypnotic effects; it was studied during the Soviet era by Soviet scientists alongside amizil.
Pharmacology Metamizil acts as a muscarinic antagonist and, at a dose of 2 mg/kg, blocks the symptoms of parkinsonism (hypokinesia, rigidity and tremor). Metamizil was used as premedication, and is a strong sedative.
The median lethal dose following intraperitoneal administration was 118 mg/kg (mouse).
Uses It has been suggested that it be used in the treatment of neuroses in dogs and humans. Sometimes as premedication (as a tranquilliser).THE USE OF TRANQUILLISERS IN SURGERY (in Russian)
Associate Professor I. A. Petukhov As well as in the treatment of vascular parkinsonism and cerebral palsy.
Side effects The reported side effects included dizziness and a dry mouth.
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