Thomas Worthington (1773–1827) was a U.S. Senator from Ohio from 1803 to 1807 and 1810 to 1814. Senator Worthington may also refer to:
Denison Worthington (1806–1880), Wisconsin State Senate William Jackson Worthington (1833–1914), Kentucky State Senate Wilmer Worthington (1804–1873), Pennsylvania State Senate
See also William Worthing (1909–1988), Nebraska State Senate Senator Worth (disambiguation)