SR-14136 is a synthetic opioid receptor agonist from the orphine series. It acts primarily as a highly potent agonist for the kappa opioid receptor, being around 10x more potent than the reference kappa agonist U-69593, and is also an agonist at the nociceptin receptor with only slightly lower potency. It has substantially weaker activity at the mu opioid receptor, at which it is a partial agonist.
See also κ-Opioid receptor agonist J-113,397 SR-17018 Utopioid (drug class)
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