Hyperbaena axilliflora is a species of flowering plant in the family Menispermaceae. It is a shrub or small tree with leathery leaves, greenish-yellow flowers, and round green fruits. The species is native to Cuba, and was described in 1899.

Taxonomy The species was described by Ignatz Urban in 1899.

Distribution Hyperbaena axilliflora is native to the wet tropical biome of central and eastern Cuba. It grows in woods, pinelands, and thickets, at elevations of up to .

Description Hyperbaena axilliflora is a shrub or small tree that grows up to high. The branches are smooth and brown. The leaves are leathery, long, and wide. The leaf edges are smooth, or slightly undulating. The leaf stem is long.

The male inflorescences are solitary or in clusters, and grow on long stems. The male flowers are greenish-yellow, and have six sepals in two series. The outer sepals are obovate, around long, and around wide. The inner sepals are broadly obovate to ovate, around long, and around wide. The male flowers have six petals in two groups. The petals are obovate, around long, and around wide. The male flowers have six stamens.

The female inflorescences are usually solitary, and grow on long stems. The female flowers grow on stems.

The fruits are green, roughly spherical, long, and wide.

Hyperbaena axilliflora has been confused with Hyperbaena cubensis. The leaves of the two species differ in shape, and the former grows at higher elevations.

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