Apostolopoulos () is a Greek surname. Notable people with the surname include:
Alexis Apostolopoulos (born 1991), Greek footballer Andreas Apostolopoulos (1952–2021), Greek-Canadian businessman Apostolos Apostolopoulos (born 2002), Greek footballer Iasonas Apostolopoulos, Greek human rights activist and civil engineer Konstantinos Apostolopoulos (born 1993), Greek footballer Steve Apostolopoulos, Canadian businessman Vasilios Apostolopoulos (born 1988), Greek footballer