James O. Durham (born October 15, 1864) was an American politician from Maryland. He served in the Maryland House of Delegates from 1904 to 1906.

Early life James O. Durham was born on October 15, 1864, in Baltimore County, Maryland, to John L. Durham. His father was a miller. He attended public schools.

Career Durham worked as a plumber and gas fitter on Frederick Road in Baltimore. He was also a steel worker.

Durham was a Democrat. He served in the Maryland House of Delegates, representing the 3rd district, from 1904 to 1906.

Personal life Durham married. They had one daughter. He lived on Millington Avenue in Baltimore.

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