H100 or H-100 may refer to:
Technology NVIDIA H100, a GPU H.100 (computer telephony), a standard for communication between PCI cards in a computer telephony system Heathkit H100, a kit by Heathkit sold assembled as the Zenith Z-100 computer iRiver H100 series, a series of hard drive digital audio players produced by iriver
Transportation H100 series, a diesel multiple unit train in Japan Hyundai Grace, a minibus or van Hyundai Porter, a pickup truck H100, the fourth generation of Toyota HiAce