Little Italies were, to a considerable extent, the result of Italophobia. The ethnocentrism and anti-Catholicism exhibited by the earlier Anglo-Saxon and northern European settlers helped to create an ideological foundation for fixing foreignness on urban spaces occupied by immigrants. Communities of Italian Americans were established in most major industrial cities of the early 20th century. New Orleans, Louisiana was the first site of immigration of Italians into America in the 19th century, before Italy was a unified nation-state. This was before New York Harbor and Baltimore became the preferred destinations for Italian immigrants. In sharp contrast to the Northeast, most of the Southern states (with the exception of Central and South Florida and the New Orleans area) have relatively few Italian-American residents. During the labor shortage in the 19th and early 20th centuries, planters in the Deep South did attract some Italian immigrants to work as sharecroppers, but they soon left the extreme anti-Italian discrimination and strict regimen of the rural areas for the cities or other states. The state of California has had Italian-American residents since the 1850s. By the 1970s, gentrification of inner city neighborhoods and the arrival of new immigrant groups caused a sharp decline in the old Italian-American and other ethnic enclaves. Many Italian Americans moved to the rapidly growing Western states. Today, New York and New Jersey have the largest numbers of Italian Americans in the U.S. while smaller Northeastern cities such as Pittsburgh, Providence and Hartford have the highest percentage of Italian Americans in their metropolitan areas.

The New York-based daily newspaper Il Progresso Italo-Americano had a national audience and reflected the views of the leadership of the community. It was published 1880–1988.Guido Rossi, "Il progresso Italo-Americano and its portrayal of Italian-American Servicemen (1941-1945)." Nuova Rivista Storica (2023) 107#2 pp. 759-787.

New York City

New York City is home to the largest Italian-American population in the country and the second-largest Italian population outside of Italy. Several Little Italy enclaves exist in New York City, including Little Italy, Manhattan; the Lower East Side in general; Italian Harlem, Morris Park, Belmont, Bensonhurst, Howard Beach, Ozone Park, Carroll Gardens, Greenwich Village, Middle Village, Italian Williamsburg, Bay Ridge, and the South Shore of Staten Island. Historically, Little Italy on Mulberry Street in Manhattan extends as far south as Canal Street, as far north as Bleecker, as far west as Lafayette and as far east as the Bowery. The neighborhood was once known for its large population of Italians. Today, it consists of Italian stores and restaurants. The Italian immigrants congregated along Mulberry Street in Manhattan's Little Italy to celebrate San Gennaro with a large street fair, lasting 11 days, that takes place every September. Today, much of the neighborhood has been absorbed and engulfed by Chinatown, as immigrants from China moved to the area.

Arthur Avenue in the Belmont section of New York City's northernmost borough, The Bronx, is one of the many neighborhoods considered the Bronx's "Little Italy", with Morris Park, Pelham Bay, Throggs Neck, and other Bronx neighborhoods also serving as centers of Italian-American culture.

Bensonhurst used to be heavily Italian-American, and it used to be considered the main "Little Italy" of Brooklyn. Since the late 1990s, most Italians have moved to Staten Island. The Italian-speaking community remains over 20,000 strong, according to the census of 2000. However, the Italian-speaking community is becoming "increasingly elderly and isolated, with the small, tight-knit enclaves they built around the city slowly disappearing as they give way to demographic changes". Its main thoroughfare, 18th Avenue (also known as Cristoforo Colombo Boulevard) between roughly 60th Street and Shore Parkway, is lined with predominantly small, Italian family-owned businesses—many of which have remained in the same family for several generations. 86th Street is another popular local thoroughfare, lined by the arches of the elevated BMT West End Subway Line. The 18th Avenue Station was popularized in opening credits of Welcome Back, Kotter. Rosebank in Staten Island was another one of NYC's main areas of Italian immigrants since the 1880s, and their descendants have continued as its predominant ethnic group, exemplified by the location of the Garibaldi Memorial in the community. In recent years, the town has experienced an influx of other ethnic groups, including Eastern Europeans, various Latin nationalities as well as Asians, particularly from the Philippines. Today, the South Shore of Staten Island is the most heavily populated Italian area in the City of New York. Over 95% of the South Shore is Italian. The neighborhoods of the South Shore with large percentages of Italians are Huguenot, Annadale, Eltingville, and Tottenville. Howard Beach in the Queens is also home to a large Italian population.

During the beginning of the Cold War, immigration into the United States from Italy was almost impossible. Americas were frightened that these immigrants could be terrorists, thus preventing Italians from gaining citizenship. As the Cold War continued, organization groups such as the Italian American Organization and the American Committee on Italian Migration (ACIM) started to form. They created vast efforts to provide assistance and aid to Italian immigrants coming into the United States. Throughout the Cold War, these organizations increased rapidly with many American Italian members as well as many new coming Italians. ACIM also took a leading role in directing the efforts of other Italian American and Catholic organizations that helped contribute to Italian immigration. These organizations provided new migrants with housing, clothing, access to job interviews, and education for children. Immediately after the Cold War period, Italian Americans further consolidated and solidified their status as members of the American mainstream.Battisti, Danielle. "The American Committee on Italian Migration, Anti-Communism, and Immigration Reform." Leatherby Libraries, Board of Trustees of the University of Illinois Press, 2012.

Philadelphia

Philadelphia's Italian American community is the second-largest in the United States. Italian Americans compose 21% of South Philadelphia's 163,000 people, and the area has numerous Italian stores and restaurants. Philadelphia is well known for its Italian Market in South Philadelphia. The Italian Market is the popular name for the South 9th Street Curb Market, an area of Philadelphia featuring many grocery shops, cafes, restaurants, bakeries, cheese shops, and butcher shops, many with an Italian influence.

Boston

The North End in Boston since the early 20th century became the center of the Italian community of Boston. It is still largely residential and well known for its small, authentic Italian restaurants and for the first Italian cafe, Caffe Vittoria. The influx of Italian inhabitants has left a lasting mark on the area; many seminal Italian American. The Italians peaked at over 44,000.

Newark

In its heyday, Seventh Avenue in Newark was one of the largest Little Italy neighborhoods in the U.S., with a population of 30,000, in an area of less than a square mile. The center of life in the neighborhood was St. Lucy's Church, founded by Italian immigrants in 1891. Throughout the year, St. Lucy's and other churches sponsored processions in honor of saints that became community events. The most famous procession was the Feast of St. Gerard, but there were also great feasts for Our Lady of Mt. Carmel, Our Lady of Snow, the Assumption, and St. Rocco. One of the nation's largest Italian newspapers, The Italian Tribune, was founded on Seventh Avenue. Seventh Avenue was notoriously devastated by urban renewal efforts during the 1950s. Eighth Avenue was obliterated by the city council, scattering the Italian American residents. Most of its businesses never recovered. The construction of Interstate 280 also served to cut the neighborhood off from the rest of the city. After the devastating urban renewal, some of the First Ward's Italians stayed in the neighborhood, while others migrated to other Newark neighborhoods like Broadway, Roseville and the Ironbound.

Chicago The neighborhood around Chicago's Taylor Street has been called the port of call for Chicago's Italian American immigrants. Taylor Street's Little Italy was home to Hull House, an early settlement house, founded by Jane Addams and Ellen Starr in 1889. Chicago's Italian American experience begins with the mass migration from the shores of southern Italy, the Hull House experiment, the Great Depression, World War II, and the machinations behind the physical demise of a neighborhood by the University of Illinois in 1963.

Italian Americans dominated the inner core of the Hull House neighborhood, 1890s–1930s.

As suburbs grew in the post-World War II era, Chicago's Italian American population spread from the central city, such as to Elmwood Park. Harlem Avenue, "La Corsa Italia", is lined with Italian stores, bakeries, clubs and organizations. The Feast of our Lady of Mount Carmel, in nearby Melrose Park, has been a regular event in the area for more than one hundred years. The near-west suburbs of Melrose Park, Schiller Park, Franklin Park, River Grove, Norridge, Chicago Heights, and Harwood Heights are also home to many Italian Americans. West suburban Stone Park is home of Casa Italia, an Italian American cultural center.

Northwest of Chicago, the city of Rockford has a large population of Italian Americans. Other historical Italian American communities in Illinois include Peoria, Ottawa, Herrin, Quad Cities and the Metro East suburbs of Saint Louis, Missouri.

Milwaukee Italians first came to Milwaukee, Wisconsin, in the late 19th century. Then in the 19th and 20th centuries large numbers of Italian immigrants began to come in mainly from Sicily and southern Italy. Brady Street, the historic Third Ward and the east side of Milwaukee is considered the heart of Italian immigration to the city, where as many as 20 Italian grocery stores once existed on Brady Street alone. Every year the largest Italian American festival in the United States, Festa Italiana, takes place in Milwaukee. Italian Americans number at around 16,992 in the city, but in Milwaukee County they number at 38,286.

St. Louis Italian immigrants from the northern Italian region of Lombardy came to St. Louis in the late 19th century and settled in the region called The Hill. As the city grew, immigrants from Southern Italy settled in a different neighborhood north of Downtown St Louis. As of 2021 there are approximately 2,000 native born Italians living in St. Louis, few of whom live in The Hill neighborhood. Italians today live mostly throughout the St. Louis metropolitan region. The Italian Community of St. Louis (Comunita' Italiana di St. Louis), an organization that promotes the Italian language and culture, has several popular events which include Carnevale which occurs every February and Ferragosto which occurs each August. The St. Louis Italian Language Program also exists on the Hill at Gateway Science Academy on Fyler Avenue. The 2005 film The Game of Their Lives is based on the true story of the 1950 U.S. soccer team, which, against all odds, beat England 1–0 in the city of Belo Horizonte, Brazil, during the 1950 FIFA World Cup. The story is about the family traditions and passions that shaped the players who made up this team of underdogs, a significant number of whom were from The Hill neighborhood of St. Louis.

Los Angeles