Sophronius of Jerusalem was a father of the church and the patriarch of Jerusalem from 634 until 638.

Sophronius of Jerusalem may also refer to:

Sophronius II of Jerusalem, patriarch (after 1048–1076/1083) , patriarch (13th century) Sophronius IV of Jerusalem, patriarch (before 1291 – before 1303) Sophronius V of Jerusalem, patriarch (1771–1774), also Patriarch Sophronius II of Constantinople