Sergio Osmeña (1878−1961), also known as Sergio Osmeña Sr., was a Filipino politician who served as the 4th President of the Philippines from 1944 to 1946.
Sergio Osmeña may also refer to:
People Sergio Osmeña Jr. (1916−1984), also known as Sergio "Serging" Veloso Osmeña Jr., Filipino politician, senator and the 13th Mayor of Cebu City Serge Osmeña (born 1943), also known as Sergio "Serge" de la Rama Osmeña III, Filipino politician and senator
Places Sergio Osmeña Jr. Bridge, popularly known as the Mactan–Mandaue Bridge, a bridge in Cebu, Philippines Sergio Osmeña, Zamboanga del Norte, a municipality in Zamboanga del Norte, Philippines