Mohammadzadeh or Mohammedzadeh () is a surname. Notable people with the surname include:
Behzad Mohammadzadeh, Iranian hacker Karim Mohammedzadeh, Iranian dissident Mehdi Mohammadzadeh (born 1984), Iranian football coach and former player Navid Mohammadzadeh, Iranian actor Saber Mohammadzadeh, Iranian communist Sahand Noor Mohammadzadeh, Iranian bodybuilder Vahid Mohammadzadeh (born 1989), Iranian football centre-back
See also Khalil Rashid-Mohammadzadeh (born 1953), Iranian Greco-Roman wrestler